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The method of fluorescent in situ hybridization (FISH) helps identify numerical and structural chromosome aberrations (deviations) using specific fluorescently labelled DNA probes.

The screening is usually performed in the chromosomes 13, 18, 21, X and Y, which are the most common cause chromosomal aberrations, and is often accompanied by the examination of chromosomes 15, 16 and 22, where numerous variations are found in aborted foetuses.